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doi: 10.1002/cbf.3613 193 JungJHSeokHChoiSJBaeJLeeSHLeeMHet al

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They are formed by polarized epithelial cells that adhere to specialized intercellular connections such as tight junctions and intercellular adhesion molecules ( Mechanistic studies have demonstrated that PM, including DEP, can impair ciliary function, induce epithelial permeability, and lead to inflammatory changes, while modulating the proliferation and death of airway epithelial cells ( Airway and lung remodeling include the main structural changes observed in chronic respiratory diseases, such as COPD, asthma ( In this review, we focus on the direct and indirect effects of PM on mucociliary activity, airway epithelial barrier function, airway inflammation, epithelial plasticity, and airway remodeling, and discuss the underlying mechanisms